Clinical Pharmacology

Coalition promotes important acetaminophen dosing reminders

November 18, 2014

It may come as a surprise that each year Americans catch approximately 1 billion colds, and the Centers for Disease Control and Prevention estimates that as many as 20% get the flu. This cold and flu season, 7 in 10 patients will reach for an over-the-counter (OTC) medicine to treat their coughs, stuffy noses, and sniffles. It’s an important time of the year to remind patients to double check their medicine labels so they don’t double up on medicines containing acetaminophen.

Support consumer access to specialty medications through value-based insurance design

June 30, 2014

The driving force behind consumer cost-sharing provisions for specialty medications is the acquisition cost and not clinical value. This appears to be true for almost all public and private health plans, says a new report from researchers at the University of Michigan Center for Value-Based Insurance Design (V-BID Center) and the National Pharmaceutical Council (NPC).

Management of antipsychotic medication polypharmacy

June 13, 2013

Within our healthcare-driven society, the increase in the identification and diagnosis of mental illnesses has led to a proportional increase in the prescribing of psychotropic medications. The prevalence of mental illnesses and subsequent treatment approaches may employ monotherapy as first-line treatment, but in many cases the use of combination of therapy can occur, leading to polypharmacy.1 Polypharmacy can be defined in several ways but it generally recognized as the use of multiple medications by one patient and the most common definition is the concurrent use of five more medications. The presence of polyharmacy has the potential to contribute to non-compliance, drug-drug interactions, medication errors, adverse events, or poor quality of life.

Medical innovation improves outcomes

June 12, 2013

I have been diagnosed with stage 4 cancer of the pancreas, a disease that’s long been considered not just incurable, but almost impossible to treat-a recalcitrant disease that some practitioners feel has given oncology a bad name. I was told my life would be measured in weeks.

FDA warns against prolonged use of magnesium sulfate to stop preterm labor

June 04, 2013

FDA advised healthcare professionals not to use magnesium sulfate injection for more than 5-7 days to stop preterm labor in pregnant women, according to a May 30 drug safety communication.

Study: Smoking cessation products effective

June 04, 2013

Nicotine replacement therapy (NRT), the antidepressant bupropion, and the drug varenicline can help smokers quit, according to a new systematic review published in The Cochrane Library.

Congressional coalition rallies against CMS ban on pharmacy home deliveries of diabetes testing supplies

June 04, 2013

Forty-three members of Congress are urging the Centers for Medicare and Medicaid Services (CMS) not to implement a new policy that prohibits independent community pharmacies from providing same-day, home delivery of diabetes testing supplies (DTS) to homebound seniors.

Disinfecting all ICU patients significantly reduces MRSA

May 30, 2013

Decolonization of all intensive care unit (ICU) patients with antimicrobial soap and ointment significantly reduces all bloodstream infections, including methicillin-resistant Staphylococcus aureus (MRSA), according to a study published in the New England Journal of Medicine.

Managed care approach to substance abuse treatment

May 20, 2013

An examination of people’s behaviors as they relate to drug use in the 20th century has shown that people will expend a large amount of energy to acquire any agent that has the ability to alter their minds, bodies, or behaviors in order to achieve a euphoric effect.

Guideline recommendations issued for molecular testing, targeted therapies in lung cancer

April 08, 2013

The College of American Pathologists (CAP), International Association for the Study of Lung Cancer (IASLC), and Association for Molecular Pathology (AMP) recently issued evidence-based guidelines on molecular testing in lung cancer, and support the recommendation that physicians conduct testing in advanced non-small cell lung cancer patients at the time of diagnosis or at the time of recurrence or progression.

Physician dispensing costs triple that of retail

February 28, 2013

A recent study shows how much physician dispensing is costing states.

Sirturo (Bedaquiline)

February 28, 2013

New molecular entity: Late last year FDA approved bedaquiline tablets for the treatment of pulmonary multi-drug-resistant tuberculosis (MDR-TB).

Researchers seek next class of anti-allergics

February 28, 2013

Allergy season is almost upon us and anti-histamine agents remain the top choice. However, researchers are looking for new medications to help patients with different needs.

High calcium intake could raise CV mortality in women

February 28, 2013

A high calcium intake, from diet or the combination of diet and supplements may raise the rate of mortality, especially cardiovascular (CV) mortality.

Patients who adhere to statin regimens are healthier, but higher drug spending makes overall care more costly

February 28, 2013

Individuals with high cholesterol who stay on their statin medications over a 2-year period are healthier than comparable nonadherent individuals, but the overall cost of their care is slightly higher, according to a new study.

Female sexual disorders: Treatment options in the pipeline

February 28, 2013

For patients with sexual disorders, there's been very little help, but a review of the pipeline indicates that help might soon be on the way.

Pipeline Preview

February 28, 2013

Recent FDA action (through February 2013) related to, rintatolimod, insulin degludec, insulin degludec/insulin aspart, dolutegravir, Radium-223 dichloride, APG101, LG631-CD34, Placental eXpanded, buprenorphine hydrochloride, naloxone HCI dihydrate, doxorubicin hydrochloride, clindamycin in 5% dextrose, Adderall

Aspirin use linked to age-related macular degeneration

February 28, 2013

Regular use of aspirin was associated with a 2-fold greater risk of developing the neovascular subtype of age-related macular degeneration (AMD) than in non-users.

FDA Actions in Brief February 2013

February 28, 2013

Recent FDA Approvals (through February 2013) related to (Ado-trastuzumab, Kadcyla, Genentech, Everolimus, Zortress, Novartis, Adapalene, benzoyl peroxide, Epiquo, Galderma, pomalidomide, Pomalyst, Celgene, alogliptin, Nesina, Takeda Pharmaceuticals, Kazano, Oseni, imatinib, Gleevec, mesalamine, Delzicol, Warner Chilcott, mipomersen sodium, Kynamro, Genzyme, Isis Pharmaceuticals, Merck, Oxutrol for Women, glycerol phenylbutyrate, Ravicti, Hyperion Therapeutics, pneumococcal 13-valent Conjugate Vaccine, Prevnar 13, Pfizer

Low-dose contraceptive patch comparable to combination oral contraceptive in safety, tolerability study

February 28, 2013

A low-dose contraceptive patch is comparable to combination oral contraceptive in a comparative study, according to phase 3 data presented at the American College of Obstetricians and Gynecologists' (ACOG) 60th Annual Clinical Meeting.